Bioreactor를 이용한 골 조직 공학에 대한 고찰
Bone tissue engineering with bioreactors
전재윤, 정주련, 심광섭, 박창주, 황경균,
소속 상세정보
전재윤 ( Jeon Jae-Yun ) - 한양대학교 의과대학 치과학교실 구강악안면외과학교실
정주련 ( Chung Joo-Ryun ) - 한양대학교 의과대학 치과학교실 구강악안면외과학교실
심광섭 ( Shim Kwang-Sub ) - 한양대학교 의과대학 치과학교실 구강악안면외과학교실
박창주 ( Park Chang-Joo ) - 한양대학교 의과대학 치과학교실 구강악안면외과학교실
황경균 ( Hwang Kyung-Gyun ) - 한양대학교 의과대학 치과학교실 구강악안면외과학교실
KMID : 1025720140330030063
Abstract
Reconstruction and regeneration of segmental defects and the atrophic maxilla and mandible have been performed using various techniques. Traditionally, the concept of guided bone regeneration has required reconstruction with autogenous particulate bone graft. One of the disadvantages of the guided bone regeneration is that it needs additional surgery. Also, it has the limitation of processing allogenic and heterogenic bone, not including bone-forming cells. The investigation of reconstructing defects using tissue-engineering utilizes the convergence of engineering and basic research advances in life science to solve the limitations. For tissue transplantation, bone-forming cells which make up the tissue to be able to form a bone carrier (scaffold), growth of inducing differentiation of a cell (cell), and the bone tissue for creating a bone tissue factor (growth factor) are required. And to require a system that can fuse these factors, it can be regarded as a bioreactor which enables three-dimensional culture system of these. Recently, development in tissue engineering and clinical attempts to deal with bioreactor have been actively proceeding. In this paper we are trying to study on bone tissue engineering around the bioreactor.
키워드
Bone; Tissue engineering; Bioreactor
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